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. 1999 Nov 9;96(23):13351–13356. doi: 10.1073/pnas.96.23.13351

Figure 2.

Figure 2

Induction of IFN-γ in splenocytes in vitro by cytokine protein secreted from transfected COS-7 (A) and TS/A (B) cells. IL-18 bioassay (stimulation of IFN-γ release) was carried out as described in Materials and Methods. Means ± SD were calculated from triplicates. *, P < 0.05 versus pro-IL-18 alone in both cells; †, P < 0.0001 versus the other groups in COS-7 cells; ‡, P < 0.005 versus the other groups in TS/A cells. A, IL-12 cDNA; B, pro-IL-18 cDNA; C, pro-IL-18/ICE cDNA; D, IL-12/pro-IL-18 cDNA; E, IL-12/pro-IL-18/ICE cDNA; F, control plasmid (pNGVL-3).