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. 1999 Nov 9;96(23):13351–13356. doi: 10.1073/pnas.96.23.13351

Figure 4.

Figure 4

TS/A growth after in vivo gene gun treatment. The protocol of gene gun treatment is described in Materials and Methods. Arrows indicate the days when gene gun treatments were performed. Mean tumor size ± SEM are shown for 15 mice per each group. A statistically significant difference in suppression of the tumor growth was observed in the group treated with IL-12/pro-IL-18/ICE, compared with that from pro-IL-18 alone (P < 0.05 on day 12 and P < 0.0001 on days 14–24), from pro-IL-18/ICE (P < 0.001 on day 14 and P < 0.0001 on days 16–24), from IL-12 alone (P < 0.05 on day 22 and P < 0.01 on day 24), and from the control plasmid (P < 0.0001 on days 12–24). □, IL-12 cDNA; ⋄, pro-IL-18 cDNA; ▵, pro-IL-18/ICE cDNA; ▿, IL-12/pro-IL-18 cDNA; ●, IL-12/pro-IL-18/ICE cDNA; ○, control plasmid (pNGVL-3).