FIG. 6.

Replication of the ORF10-to-ORF12 cluster gene mutants in human skin xenografts in SCID-hu mice in vivo. Skin xenografts were infected with POKA, POKAΔ10, POKAΔ11, POKAΔ12, POKAΔ10/11, POKAΔ11/12, or POKAΔ10/11/12. Xenografts were harvested at 10 and 21 days after inoculation, and infectious virus yields of each sample were determined by infectious focus assays. Each bar represents the mean viral titer, and error bars represent the standard deviations. The asterisks indicate significant differences in viral titers (P < 0.05) compared to those for POKA.