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Uncapped PV mRNA uses PCBP and 2APro to mediate PV mRNA and polysome stability. (A) PCBP-5′ cloverleaf interactions block 5′ exonuclease (5′ exo) as de novo polysomes form (as reported by references 23 and 31). (B) 2APro increased PV mRNA stability coincident in time with cleavage of eIF4G (after 20 min of translation as reported herein). The diagram of eIF4G was adapted from reference 40.
