FIG. 2.

Kinetics of major lymphocyte populations and subsets (absolute counts) in peripheral blood from SIVmnd-1-infected mandrill dames. SIVmnd-1 infection induced significant depletion at the peak of viral replication of CD4⁺ T cells (a). During chronic infection, the quantity of CD4⁺ T cells rebounded to near preinfection values (a). At the peak of viral replication, the effector memory CD4⁺ T cells (defined as CD4⁺ CD28⁻) were significantly depleted in peripheral blood (b). No significant changes were observed for the kinetics of CD8⁺ T cells (c) and CD20 cells (d).