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EGFP-tagged isogenic recombinant viruses differ in the spike gene. A schematic diagram of the replacement of gene 4a and part of gene 4b in the MHV genome expressing EGFP. SJHM-RA59EGFP expresses the JHM spike gene, RA59EGFP expresses the A59 spike gene, and SMHV2-RA59EGFP expresses the MHV-2 spike gene in the background of the A59 gene. All three recombinant viruses derived are isogenic, differing only in the spike gene.
