FIG. 1.
Amino acid sequences of HIV-1 MSDs. The consensus sequence of the HIV-1 MSD was generated by the alignment of the Env MSD sequences of all M and N group HIV-1 isolates from the Los Alamos HIV sequence database (updated to June 2007). The percentages of isolates with the conserved amino acid residue are shown above the consensus sequence as a bar chart. The amino acid residues of the putative MSD region are shown as uppercase letters. The flanking sequences of the HIV-1 MSD are shown as lowercase letters. The position of the MSD in the sequence of HIV-1 NL4-3 is marked above the positively charged amino acid residues. The mutated portions of the HIV-1 MSD are underlined.