Skip to main content
. 2008 Mar 19;82(11):5255–5268. doi: 10.1128/JVI.00172-08

FIG. 5.

FIG. 5.

Temporal and anatomical distributions of histopathological lesions in the CNS of monkeys following i.t. inoculation with TBEV/DEN4Δ30, LGTV, or YF 17D. (A) Temporal distributions of MGHS for the CII and MGA/ND in the entire CNS. The grading scale is described in Table S1 in the supplemental material. (B and C) Anatomical profiles of the CII (B) and MGA/ND (C) at 14, 21, and 30 dpi. MGHS did not differ statistically unless specifically noted. MGHS were significantly higher (▴) or lower (▾) compared to the previous time point (P < 0.05). MGHS for the CNS regions of the TBEV/DEN4Δ30 group of monkeys were significantly higher (P < 0.05) than those for the LGTV group (indicated with one asterisk) or the YF 17D group (indicated with two asterisks) at the same time point. MGHS for the spinal cords of LGTV-inoculated monkeys were significantly higher (P < 0.05) than those for the TBEV/DEN4Δ30 or YF 17D group on 21 dpi (indicated with three asterisks). Hemispheres: cortex, hippocampus, basal ganglia (caudate nucleus, globus pallidus, and putamen), and thalamus. Brain stem: midbrain, pons, and medulla oblongata. Spinal cord: cervical, thoracic, and lumbar regions.