TABLE 1.

Experimental design of the comparative neuropathogenesis and neurovirulence study of TBEV/DEN4Δ30, LGTV, and YF 17D in rhesus monkeys

Inoculated virus	Expt no.a	No. of animals euthanized on dpi:
		3	7	14	21	30	Total
TBEV/DEN4Δ30	2 and 3	2	2	2 + 1b,c	2 + 1b	2	12
LGTV	2 and 3	2	2	2	2 + 2b	2	12
YF 17D	3	2	2	2	4	2	12
Mock control	2 and 3	NDd	1b	1b	1b	1	4

^aBecause a large number of animals were involved in the neuropathogenesis studies, they were conducted in separate but similarly designed and executed experiments. In experiment 1, the 22 animals used were not sacrificed and are not included in this table. Experiment 2 included 21 animals, and experiment 3 included 19 animals.

^bNumber of animals in experiment 3.

^cThis monkey was scheduled to be sacrificed at 21 dpi in experiment 3 but was euthanized at 13 dpi.

^dND, not done.