FIG. 2.

Mutant viruses do not revert. Sequence analysis of viral RNA extracted from lymph nodes 7 days after infection with V^ko (monkey 886 infected with V^ko [886-V^ko]) or C^ko (monkey 957 infected with C^ko [957-C^ko]). Sequences are also shown above the chromatograms. They cover the C start codon (shown in bold type) on the left side panel, and the RNA editing site (in bold type) on the right side panel. The wild-type sequences are shown above the left top panel (wt,V^ko) and the right bottom panel (wt,C^ko). Mutations are indicated in lowercase type. Relevant nucleotides are highlighted with colored asterisks as follows: for 957-C^ko, inactivation of the C-protein start codon (blue asterisk), mutation to a stop codon (green asterisk), and wild-type sequence covering the editing site region (two green asterisks); for 886-V^ko, an inactivated editing site (right side, mutation to G, black asterisk) followed by a TGA stop codon (red asterisk) and wild-type sequence covering the C protein ATG start codon (red asterisks), and the TGG tryptophan codon (black asterisk).