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. 2008 Mar 19;82(11):5450–5459. doi: 10.1128/JVI.01952-07

FIG. 2.

FIG. 2.

Epitope mapping: an HIV-specific non-T-lymphocyte response recognizes Vpu peptide. Whole blood from subject 26 was incubated with HIV peptides for 5 h, and gated lymphocytes were studied for the expression of CD3 and IFN-γ. (A) The recognition of pooled Tat, Rev, and Vpu peptide (shown in Fig. 1B) was specific for a Vpu pool of 19 peptides. (B) Individual peptides within the Vpu pool of 19 peptides were studied, with the response overlapping peptides 18 and 19. (C and D) The Vpu response was mapped to minimal epitopes. A 14-mer peptide had an equally strong response to larger peptides.