TABLE 2.

Comparisons of the mean d_S and d_N between the inoculum and time of death in virus sequences in rhesus macaques

Mamu-B*17 expression	Gene or region	Mean dS ± SE	Mean dN ± SE or significance	dS = dN?a
Positive (31 macaques)	vif
	Vif HW8	0.0113 ± 0.0083	0.0308 ± 0.0049	NSc
	Remainder	0.0023 ± 0.0008	0.0061 ± 0.0007	P < 0.01
	nef
	Nef IW9	0.0263 ± 0.0070	0.0789 ± 0.0083	P < 0.001
	Nef MW9	0.0104 ± 0.0054	0.0426 ± 0.0042	P < 0.001
	Remainder	0.0041 ± 0.0015	0.0114 ± 0.0016	P < 0.01
Negative (31 macaques)	vif
	Vif HW8	0.0000 ± 0.0000	0.0182 ± 0.0018	NS
	Remainder	0.0010 ± 0.0006	0.0033 ± 0.0007	NS
	nef
	Nef IW9	0.0000 ± 0.0000	0.0099 ± 0.0039	NS
	Nef MW9	0.0000 ± 0.0000	0.0023 ± 0.0017	NS
	Remainder	0.0011 ± 0.0006	0.0080 ± 0.0019	P < 0.01
B*17+dN = B*17−dNb	vif
	Vif HW8		P < 0.001
	Remainder		P < 0.05
	nef
	Nef IW9		P < 0.001
	Nef MW9		P < 0.001
	Remainder		NS

^aTests of the hypothesis (two-sample t test, Bonferroni corrected) that d_S was equal to d_N in Mamu-B*17-restricted epitopes and in the remaining gene sequence.

^bTests of the hypothesis (two-sample t test, Bonferroni corrected) that d_N for Mamu-B*17⁺ animals equals the corresponding value for Mamu-B*17⁻ animals.

^cNS, not significant.