TABLE 2.
Mamu-B*17 expression | Gene or region | Mean dS ± SE | Mean dN ± SE or significance | dS = dN?a |
---|---|---|---|---|
Positive (31 macaques) | vif | |||
Vif HW8 | 0.0113 ± 0.0083 | 0.0308 ± 0.0049 | NSc | |
Remainder | 0.0023 ± 0.0008 | 0.0061 ± 0.0007 | P < 0.01 | |
nef | ||||
Nef IW9 | 0.0263 ± 0.0070 | 0.0789 ± 0.0083 | P < 0.001 | |
Nef MW9 | 0.0104 ± 0.0054 | 0.0426 ± 0.0042 | P < 0.001 | |
Remainder | 0.0041 ± 0.0015 | 0.0114 ± 0.0016 | P < 0.01 | |
Negative (31 macaques) | vif | |||
Vif HW8 | 0.0000 ± 0.0000 | 0.0182 ± 0.0018 | NS | |
Remainder | 0.0010 ± 0.0006 | 0.0033 ± 0.0007 | NS | |
nef | ||||
Nef IW9 | 0.0000 ± 0.0000 | 0.0099 ± 0.0039 | NS | |
Nef MW9 | 0.0000 ± 0.0000 | 0.0023 ± 0.0017 | NS | |
Remainder | 0.0011 ± 0.0006 | 0.0080 ± 0.0019 | P < 0.01 | |
B*17+dN = B*17−dNb | vif | |||
Vif HW8 | P < 0.001 | |||
Remainder | P < 0.05 | |||
nef | ||||
Nef IW9 | P < 0.001 | |||
Nef MW9 | P < 0.001 | |||
Remainder | NS |
Tests of the hypothesis (two-sample t test, Bonferroni corrected) that dS was equal to dN in Mamu-B*17-restricted epitopes and in the remaining gene sequence.
Tests of the hypothesis (two-sample t test, Bonferroni corrected) that dN for Mamu-B*17+ animals equals the corresponding value for Mamu-B*17− animals.
NS, not significant.