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. 2008 Apr 2;82(11):5245–5254. doi: 10.1128/JVI.00292-08

TABLE 2.

Comparisons of the mean dS and dN between the inoculum and time of death in virus sequences in rhesus macaques

Mamu-B*17 expression Gene or region Mean dS ± SE Mean dN ± SE or significance dS = dN?a
Positive (31 macaques) vif
    Vif HW8 0.0113 ± 0.0083 0.0308 ± 0.0049 NSc
    Remainder 0.0023 ± 0.0008 0.0061 ± 0.0007 P < 0.01
nef
    Nef IW9 0.0263 ± 0.0070 0.0789 ± 0.0083 P < 0.001
    Nef MW9 0.0104 ± 0.0054 0.0426 ± 0.0042 P < 0.001
    Remainder 0.0041 ± 0.0015 0.0114 ± 0.0016 P < 0.01
Negative (31 macaques) vif
    Vif HW8 0.0000 ± 0.0000 0.0182 ± 0.0018 NS
    Remainder 0.0010 ± 0.0006 0.0033 ± 0.0007 NS
nef
    Nef IW9 0.0000 ± 0.0000 0.0099 ± 0.0039 NS
    Nef MW9 0.0000 ± 0.0000 0.0023 ± 0.0017 NS
    Remainder 0.0011 ± 0.0006 0.0080 ± 0.0019 P < 0.01
B*17+dN = B*17dNb vif
    Vif HW8 P < 0.001
    Remainder P < 0.05
nef
    Nef IW9 P < 0.001
    Nef MW9 P < 0.001
    Remainder NS
a

Tests of the hypothesis (two-sample t test, Bonferroni corrected) that dS was equal to dN in Mamu-B*17-restricted epitopes and in the remaining gene sequence.

b

Tests of the hypothesis (two-sample t test, Bonferroni corrected) that dN for Mamu-B*17+ animals equals the corresponding value for Mamu-B*17 animals.

c

NS, not significant.