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Model depicting the topology of HSV-2 UL56 and its interaction with Nedd4. UL56 localizes to the Golgi apparatus and cytoplasmic vesicles. UL56 possesses a hydrophobic segment near its C terminus, which anchors it to the lipid bilayer, while its N terminus resides in the cytoplasm. UL56 binds to Nedd4 via its PY motifs, which are contained in its N-terminal domain. UL56 is not ubiquitinated by Nedd4 but can increase the ubiquitination of Nedd4 and promote its degradation.
