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Deletion of UL56 does not affect viral growth in Vero cells and undifferentiated SK-N-SH cells. Vero (A) and SK-N-SH (B) cells were infected with wild-type (186), ΔUL56Z, or ΔUL56Zrev HSV-2 at an MOI of 3 (single-step) or 0.003 (multistep), harvested at the indicated times postinfection, and titrated as described in Materials and Methods. The replication patterns of wild-type, ΔUL56Z, and ΔUL56Zrev viruses in Vero and SK-N-SH cells were virtually identical.
