Table 2.
Significant correlations between BMI and expression profiles of genes annotated with themes composing the GO Biological Process interaction modules in obese WAT
| EntrezGene gene ID | Gene symbol | Gene name | Fold* | Rs† | FDR‡ | Tissular fraction§ |
|---|---|---|---|---|---|---|
| Module 1 | ||||||
| 1880 | EBI2 | Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor) | 1.63 | 0.62 | 0.00 | SVF |
| 5788 | PTPRC | protein tyrosine phosphatase,receptor type,C | 1.74 | 0.61 | 0.00 | SVF |
| 1520 | CTSS | cathepsin S | 1.53 | 0.54 | 0.00 | SVF |
| 51107 | APH1A | anterior pharynx defective 1 homolog A | 1.40 | 0.50 | 0.01 | SVF |
| 1439 | CSF2RB | colony stimulating factor 2 receptor,beta,low-affinity (granulocyte-macrophage) | 2.03 | 0.49 | 0.01 | SVF |
| 3937 | LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76 kDa) | 1.87 | 0.49 | 0.01 | SVF |
| 919 | CD247 | CD247 molecule | 1.36 | 0.49 | 0.01 | SVF |
| 3301 | DNAJA1 | DnaJ (Hsp40)homolog,subfamily A,member 1 | 1.46 | 0.48 | 0.02 | SVF |
| 131566 | DCBLD2 | discoidin,CUB and LCCL domain containing 2 | 2.00 | 0.47 | 0.02 | - |
| 9448 | MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 1.40 | 0.47 | 0.02 | - |
| 3091 | HIF1A | hypoxia-inducible factor 1,alpha subunit (basic helix-loop-helix transcription factor) | 1.32 | 0.46 | 0.02 | SVF |
| 11183 | MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 1.35 | 0.44 | 0.03 | A |
| 23678 | SGK3 | serum/glucocorticoid regulated kinase family,member 3 | 1.48 | 0.44 | 0.03 | - |
| 667 | DST | dystonin | 1.66 | 0.44 | 0.03 | SVF |
| 10954 | PDIA5 | protein disulfide isomerase family A,member 5 | 1.34 | 0.43 | 0.03 | - |
| 2113 | ETS1 | v-ets erythroblastosis virus E26 oncogene homolog 1 | 1.65 | 0.41 | 0.03 | - |
| 8506 | CNTNAP1 | contactin associated protein 1 | 1.24 | 0.41 | 0.03 | SVF |
| 10437 | IFI30 | interferon,gamma-inducible protein 30 | 2.35 | 0.40 | 0.04 | SVF |
| 10095 | ARPC1B | actin related protein 2/3 complex,subunit 1B,41 kDa | 1.74 | 0.39 | 0.04 | SVF |
| Module 2 | ||||||
| 5256 | PHKA2 | phosphorylase kinase,alpha 2 | 0.67 | -0.67 | 0.00 | A |
| 3643 | INSR | insulin receptor | 0.67 | -0.66 | 0.00 | - |
| 23604 | DAPK2 | death-associated protein kinase 2 | 0.44 | -0.61 | 0.00 | A |
| 1384 | CRAT | carnitine acetyltransferase | 0.62 | -0.61 | 0.00 | A |
| 1968 | EIF2S3 | eukaryotic translation initiation factor 2,subunit 3 gamma,52 kDa | 0.63 | -0.58 | 0.00 | - |
| 11000 | SLC27A3 | solute carrier family 27 (fatty acid transporter),member 3 | 0.76 | -0.56 | 0.01 | SVF |
| 10572 | SIVA1 | CD27-binding (Siva)protein | 0.69 | -0.54 | 0.01 | A |
| 6158 | RPL28 | ribosomal protein L28 | 0.66 | -0.53 | 0.01 | SVF |
| 6206 | RPS12 | ribosomal protein S12 | 0.53 | -0.52 | 0.01 | SVF |
| 11224 | RPL35 | ribosomal protein L35 | 0.65 | -0.51 | 0.01 | SVF |
| 6187 | RPS2 | ribosomal protein S2 | 0.77 | -0.51 | 0.01 | - |
| 51069 | MRPL2 | mitochondrial ribosomal protein L2 | 0.59 | -0.50 | 0.01 | A |
| 93974 | ATPIF1 | ATPase inhibitory factor 1 | 0.79 | -0.49 | 0.01 | - |
| 134 | ADORA1 | adenosine A1 receptor | 0.75 | -0.48 | 0.01 | A |
| 51023 | MRPS18C | mitochondrial ribosomal protein S18C | 0.74 | -0.48 | 0.01 | A |
| 35 | ACADS | acyl-CoA dehydrogenase,C-2 to C-3 short chain | 0.69 | -0.48 | 0.01 | A |
| 6227 | RPS21 | ribosomal protein S21 | 0.62 | -0.48 | 0.02 | SVF |
| 4694 | NDUFA1 | NADH dehydrogenase (ubiquinone)1 alpha subcomplex,1,7.5 kDa | 0.86 | -0.48 | 0.02 | A |
| 1936 | EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | 0.75 | -0.47 | 0.02 | SVF |
| 3991 | LIPE | lipase,hormone-sensitive | 0.76 | -0.46 | 0.02 | A |
| 10063 | COX17 | COX17 cytochrome c oxidase assembly homolog | 0.71 | -0.45 | 0.02 | - |
| 5346 | PLIN | perilipin | 0.71 | -0.45 | 0.02 | A |
| 27335 | EIF3S12 | eukaryotic translation initiation factor 3,subunit 12 | 0.73 | -0.43 | 0.03 | A |
| 84545 | MRPL43 | mitochondrial ribosomal protein L43 | 0.78 | -0.43 | 0.03 | A |
| 8613 | PPAP2B | phosphatidic acid phosphatase type 2B | 0.50 | -0.42 | 0.03 | SVF |
| 1983 | EIF5 | eukaryotic translation initiation factor 5 | 0.76 | -0.42 | 0.03 | SVF |
| 1611 | DAP | death-associated protein | 0.70 | -0.40 | 0.04 | SVF |
| 6166 | RPL36AL | ribosomal protein L36a-like | 0.73 | -0.40 | 0.04 | - |
| 6152 | RPL24 | ribosomal protein L24 | 0.74 | -0.40 | 0.04 | SVF |
| 122970 | ACOT4 | acyl-CoA thioesterase 4 | 0.65 | -0.40 | 0.04 | A |
| 5255 | PHKA1 | phosphorylase kinase,alpha 1 | 0.81 | -0.39 | 0.04 | - |
| 6165 | RPL35A | ribosomal protein L35a | 0.72 | -0.39 | 0.04 | SVF |
*Gene expression fold change in the obese versus lean condition. †Spearman's correlation coefficients between gene expression profiles and the BMI of analyzed subjects. ‡The q-values obtained by applying the Storey (2002) FDR method to adjust the p values computed with the Spearman's correlation test. §Genes expressed predominantly in one of the two main cellular fractions of the adipose tissue: mature adipocytes (A) or the stroma vascular fraction (SVF). Hyphens indicate genes for which no significantly predominant expression in one of the two main cellular fractions of the adipose tissue could be detected.