Table 1. Cell cycle distribution of ECV304, H292 and A549 after incubation with ET-743 using different incubation times (24, 48 h) and time intervals (0, 4, 24 h).

	Cell cycle phases (%)
Cell line – conc. ET-743	G1	S	G2/M
ECV – 1.5 nM
Control	33.1±4.2	50.6±5.4	16.3±2.1
24 h	32.6±5.2	45.6±6.1	21.7±3.9a
24+4 h	29.9±5.5	39.4±4.7b	30.8±4.7b
24+24 h	41.1±6.1	39.4±8.6a	19.4±2.6
48 h	31.8±5.1	41.4±3.0a	26.7±4.4b
48+4 h	20.7±3.6a	43.8±4.4	35.0±4.3b
H292 – 0.75 nM
Control	60.8±4.9	22.8±3.3	16.0±1.9
24 h	51.1±1.5b	26.2±1.1	22.3±1.9a
24+4 h	49.7±3.5a	25.3±2.7	24.8±1.9a
24+24 h	54.2±2.5	24.2±2.4	21.2±0.6
48 h	45.6±4.8b	24.2±3.1	29.6±5.6b
48+4 h	50.1±1.7a	22.9±2.4	26.4±3.5b
A549–1.8 nM
Control	57.1±1.3	27.5±1.2	14.8±1.0
24 h	13.2±1.7b	50.9±5.4b	35.6±4.8b
24+4 h	12.2±3.1b	37.7±5.4a	49.6±5.1b
24+24 h	9.2±1.4b	14.6±3.1a	73.6±1.9b
48 h	10.5±1.3b	17.7±4.8a	67.4±3.3b
48+4 h	8.7±0.9b	15.7±2.3a	72.3±2.0b

^ap<0.05 vscontrol.

^bp<0.005 vs control.