Table 1. Diagnosis and monitoring of imatinib-sensitive disorders.

Disorder	Genetics	Diagnosis	Monitoring
CML	BCR-ABL fusion	Karyotype, PCR	Karyotype quantitative PCR BCR-ABL mutation screening
Hyper-eosinophilic syndromes	Various involving PDGFRA and PDGFRB	Karyotype, PCR	Karyotype quantitative PCR mutation screening
Systemic mastocytosis	C-KIT activating mutation	KIT immunohistochemistry, C-KIT mutation detection
Gastrointestinal stromal tumours	C-KIT activating mutation	KIT immunohistochemistry, C-KIT mutation detection	PET