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. 2004 Jan 6;90(1):12–19. doi: 10.1038/sj.bjc.6601507

Table 2. IC50 values for BCR-ABL mutations.

  IC50 (μM imatinib)
BCR-ABL type Corbin (2003) Azam (2003) Hochhaus (2002) Shah (2002) Von Bubnoff (2002)
Wild-type ABL     0.025    
Wild-type BCR-ABL 0.5 0.6   0.6 >0.1<0.5
M244V 1.6 3.1      
M244I   1.4      
G250E 4.5 >20   >10  
Q252H 2.6 2.9      
Y253H >17.7 17.7 3.7   >10
Y253F 5.0   1.8    
E255V >17.7   >5   >10
E255K 7.5 12.1 >5 >10 >10
F311L 0.7 1.3      
T315I >17.7 >20   >10 >10
T315S   3.8      
F317L 1.3 2.3   7.5  
M351T 1.5 4.9   4.4  
M351I   1.6      
E355G 2.0     2.4  
F359V 1.4        
V379I 1.0        
L387M 1.1        
H396P 4.3       >1.0<5.0
H396R 5.4