Table 3. Toxicities of EMP/VBL and EMP (NCIC-CTG).
|
No of patients with NCIC-CTG grade toxicity |
|||||
|---|---|---|---|---|---|
| Type of toxicity | 1 | 2 | 3 | 4 | % |
| (a) EMP/VBL | |||||
| Cardiovasculara | 1 | 5 | 4 | 2b | 27.9 |
| Gynecomastia | 13 | 1 | 32.6 | ||
| Diarrhoea | 4 | 1 | 2 | 16.3 | |
| Nausea | 8 | 8 | 3 | 44.2 | |
| Vomiting | 5 | 3 | 18.6 | ||
| Other gastrointestinac | 3 | 3 | 1 | 16.3 | |
| Alopecia | 4 | 9.3 | |||
| Neurologicald | 6 | 4 | 2 | 27.9 | |
| Bilirubin rise | 2 | 1 | 1 | 9.3 | |
| SGOT rise | 13 | 1 | 32.6 | ||
| Platelets | 8 | 1 | 20.9 | ||
| Haemoglobin | 18 | 15 | 1 | 76.7 | |
| WBC | 4 | 1 | 11.6 | ||
| (b) EMP | |||||
| Cardiovasculare | 3 | 5 | 4 | 26.7 | |
| Gynecomastia | 6 | 7 | 28.9 | ||
| Diarrhoea | 6 | 1 | 1 | 17.8 | |
| Nausea | 9 | 11 | 5 | 55.6 | |
| Vomiting | 9 | 5 | 1 | 1 | 35.6 |
| Other gastrointestinalf | 4 | 3 | 1 | 17.8 | |
| Alopecia | 4 | 1 | 11.1 | ||
| Neurologicalg | 3 | 7 | 3 | 28.9 | |
| Bilirubin rise | 5 | 3 | 2 | 22.2 | |
| SGOT rise | 9 | 2 | 24.4 | ||
| Platelets | 6 | 1 | 1 | 17.8 | |
| Haemoglobin | 23 | 8 | 2 | 73.3 | |
| WBC | 2 | 2.2 | |||
a
Cardiovascular toxicity: venous thrombosis 2, oedema, pulmonary embolism, myocardial infarction, atrial fibrillation, insufficient cardiac function.
b
2 deaths (myocardial infarction, stroke).
c
Two other gastrointestinal toxicity: abdominal pain 2, sensitive oesophagus, pyrosis.
d
Neurological toxicity: constipation 4, depression 2, muscle cramping 2, paresthesia.
e
Cardiovascular toxicity: oedema 7, venous thrombosis 2, pulmonary embolism, atrial fibrillation, insufficient cardiac function.
f
Other gastrointestinal toxicity: anorexia 4, abdominal pain 3.
g
Neurological toxicity: constipation 8, depression, muscle cramping, paresthesia.