Abstract
A controlled field trial to determine the efficacy of a single dose of an aluminium phosphate-adsorbed cholera vaccine was conducted in Calcutta during 1975-77. An aluminium phosphate-adsorbed tetanus toxoid was used as the placebo. Follow-up of the immunized volunteers for a period of two years showed that the adsorbed cholera vaccine provided 100% protection to children under five years of age for 6 months, 88.9% for 12 months, and 91.7% for 18 months (P<0.05). The overall protection for all age groups was 58.5% for 18 months. There were no serious side effects following the anti-cholera inoculations.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Azurin J. C., Cruz A., Pesigan T. P., Alvero M., Camena T., Suplido R., Ledesma L., Gomez C. Z. A controlled field trial of the effectiveness of cholera and cholera El Tor vaccines in the Philippines. Bull World Health Organ. 1967;37(5):703–727. [PMC free article] [PubMed] [Google Scholar]
- Joó I., Csizér Z., Juhász V. P. Immune response to plain and adsorbed cholera vaccines. Prog Immunobiol Stand. 1971;5:350–354. [PubMed] [Google Scholar]
- Saroso J. S., Bahrawi W., Witjaksono H., Budiarso R. L., Brotowasisto, Bencić Z., Dewitt W. E., Gomez C. Z. A controlled field trial of plain and aluminium hydroxide-adsorbed cholera vaccines in Surabaya, Indonesia, during 1973--75. Bull World Health Organ. 1978;56(4):619–627. [PMC free article] [PubMed] [Google Scholar]