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. 2008 Apr 25;9:214. doi: 10.1186/1471-2105-9-214

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Copyright © 2008 Daigle and Altman; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparing M-BISON and GeneRank performance on the hsf1 dataset. ROC curves for single parameter M-BISON, empirical M-BISON, the best performance of GeneRank (d = .99), and GeneRank with recommended d of .5 are shown. Both versions of M-BISON outperform the two instances of GeneRank. Notably, a comparison of the versions of M-BISON and GeneRank that do not require knowledge of the right answer – empirical (blue) and d = .5 (brown), respectively-shows that M-BISON performs significantly better in the unsupervised identification of Hsf1p bound genes.