Figure 2.

Effect of Schistosoma mansoni soluble worm proteins (SmSWPs) and Ancylostoma caninum excretory/secretory products (AcESPs) on myeloperoxidase (MPO) activity. MPO activity was measured to monitor the degree of myeloid cell infiltration in the colon. Data are presented as units MPO per gram of colon tissue and 1 unit equals the amount of MPO necessary to degrade 1 μmol of H₂O₂ to H₂O per minute at 25°C. TNBS-induced colitis caused a significant increase in MPO activity compared to control mice treated with phosphate-buffered saline (PBS). Intraperitoneal injection of helminth-derived products significantly ameliorated inflammation as shown by the significant decrease in MPO activity. Treatment of control mice with SmSWP or AcESP had no effect (data not shown). ∗ p ≤ .05, significantly different from contol PBS; # p ≤ .05, significantly different from TNBS-PBS; two way ANOVA, n = 7 − 10 [77].