Figure 4.
Alveolar epithelial STAT3 and host defense at 48 hours. Alveolar neutrophils (A) and lung bacterial clearance (B) were measured 48 hours after intratracheal E. coli in the presence and absence of alveolar epithelial STAT3. Alveolar neutrophil counts (A) were determined in control or Stat3Δ/Δ mice by morphometric analysis of histologic lung sections. Neutrophil data are presented as means ± SE (n = 9–11) of the percentage of alveolar airspace occupied by neutrophils. Bacteriology data are expressed as means ± SE (n = 5–10) of total lung CFU. *Statistically significant compared with control mice (P < 0.05).