Figure 5.
Alveolar epithelial STAT3 and lung injury. Pulmonary edema was examined 48 hours after intratracheal E. coli in the presence and absence of alveolar epithelial STAT3. Representative images are shown of pneumonic lung sections from (A) control or (B) Stat3Δ/Δ mice. Alveolar edema was quantified by morphometric analysis of lung sections (C) and data expressed as means ± SE (n = 7–8) of the percentage of alveolar space occupied by edema fluid. Pulmonary edema was also measured and expressed as means ± SE (n = 8–11) wet:dry (D). *Statistically significant compared with control mice (P < 0.05).