TABLE 2.

SPECIFIC EFFECTS OF TYROSINE SULFATION

Effect	Chemokine Receptor	Details	Reference
Increased binding of chemokines	CMV US28	Viral receptor CMV US28: Increased binding to CCL3*, CCL4†, CCL5‡, CX3CL1§	(45)
Increased binding of chemokines	CXCR3	Receptor CXCR3: Increased binding to CXCL9‖, CXCL10**, CXCL11††	(12)
	CXCR4	Receptor CXCR4: Increased binding to CXCL12‡‡	(9)
	CCR2b	Receptor CCR2b: Increased binding to CCL2§§	(10)
	CCR5	Receptor CCR5: Increased binding to CCL3*, CCL4†, and CCL5‡	(5,46)
Increased binding to chemokine/ adhesion molecules	CX3CR1	Receptor CX3CR1: Increased firm adhesion to CX3CL1§	(11)
	CXCR3	Receptor CXCR3: Increases chemotaxis after binding to CXCL9‖, CXCL10**, and CXCL11††	(12)
Increased signaling/ Downstream events	CCR2b	Receptor CCR2b: Increased Ca++ influx and chemotaxis after binding to CCL2§§	(10)
	CX3CR1	Receptor CX3CR1: Increased Ca++ influx after binding to CXC3L1§	(11)

^*CCL3/MIP-1α

^†CCL4/MIP-1β

^‡CCL5/RANTES.

^§CX3CL1/Fractalkine.

^‖CXCL9/MIG.

^**CXCL10/IP-10.

^††CXCL11/I-TAC.

^‡‡CXCL12/SDF-1.

^§§CCL2/MCP-1.