Skip to main content
. 2008 Jun 4;3(6):e2355. doi: 10.1371/journal.pone.0002355

Figure 3. The cytotoxic effects of etoposide, 5-fluorouracil, doxorubicin, and docetaxel are not associated with p38 MAPK activation in LLC11 cells.

Figure 3

A) The effect of increasing concentrations of etoposide, 5-FU, doxorubicin or docetaxel on p38 MAPK activation and proliferation were assessed by immunoblotting and MTS assay respectively. B) The effect of p38 MAPK blockade on drug-induced cytotoxicity in LLC1 cells treated with etoposide, 5-FU or doxorubicin. Note that the addition of the p38 MAPK inhibitor appeared to enhance the cytotoxic effects of 5-FU on LLC1 cells (see *).