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. 2008 Jun 4;3(6):e2366. doi: 10.1371/journal.pone.0002366

Figure 7. Relationships among transcription factors in newly generated neuronal and glial-like cell populations.

Figure 7

Both Olig2 and Sox2 are never coexpressed with Pax2 (A,B), whereas some Sox2+ nuclei also contain Olig2 (C, arrow). Virtually all BLBP+ Bergmann glia cells contain Sox2 (D) but not Olig2 (E). Some large Sox2+ nuclei in the Purkinje cell layer do incorporate BrdU at 1–5 days postinjection survival (F). Incorporation of BrdU is also detectable in some Bergmann glia cells (G; two immuno-negative Bergmann glial cells are indicated by arrows), that retain the marker for at least two months (H). P, Purkinje neuron (immuno-negative). Also Olig2+ cells can incorporate BrdU at 1–5 days postinjection survival (I). (J,K), Proliferating Sox2+ nuclei and BLBP+ Bergmann glia cells in the Purkinje cell layer of the adult rabbit. (L), Schematic summary: Pax2+ neuronal precursors and multipolar glial-like cell precursors generated in the peripuberal and adult rabbit cerebellar cortex belong to two distinct populations. Sox2+, dividing Bergmann glia could generate Sox2+/Olig2+ precursors that then express Map5 in multipolar cells. Bars: 10 µm.