Table 3.
Geometric means (95% confidence interval) of steroid hormone levels for endometrial cancer case patients and control subjects, by menopausal status at the time of blood donation
| Premenopausal women | Postmenopausal women | |||
|---|---|---|---|---|
| Hormone | Case patients | Control subjects | Case patients | Control subjects |
| SHBG (nmol/l) | 48.4 (42.2–55.5) | 51.0 (46.2–56.2) | 42.6 (39.7–45.7) | 47.9 (45.5–50.4)† |
| DHEAS (μmol/l) | 2.59 (2.19–3.06) | 2.41 (2.13–2.72) | 1.84 (1.66–2.05) | 1.89 (1.75–2.04) |
| Androstenedione (nmol/l) | 5.14 (4.65–5.69) | 4.97 (4.62–5.34) | 3.71 (3.49–3.95) | 3.75 (3.58–3.92) |
| Testosterone (nmol/l) | 1.39 (1.24–1.55) | 1.36 (1.25–1.47) | 1.32 (1.22–1.43) | 1.20 (1.14–1.28)* |
| Free testosterone (pmol/l) | 18.3 (15.7–21.2) | 17.4 (15.6–19.4) | 18.8 (17.2–20.7) | 15.9 (14.9–17.0)† |
| Estrone (pmol/l) | 138 (130–148) | 121 (116–127)† | ||
| Estradiol (pmol/l) | – | – | 98.8 (93.1–105) | 89.1 (85.3–92.9)‡ |
| Free estradiol (pmol/l) | – | – | 2.40 (2.24–2.58) | 2.09 (1.98–2.19)‡ |
*P<0.05, †P<0.01, ‡P<0.001. Analysis based on 162 premenopausal women (55 case patients and 107 control subjects) and 566 postmenopausal women (192 case patients and 374 control subjects). Measurements were not taken for estrone, estradiol, or free estradiol among premenopausal women. DHEAS, dehydroepiandrosterone sulfate; SHBG, sex hormone-binding globulin.