Figure 3.

LTP in dentate gyrus (a) and area CA1 (b). (a1, b1) Digital images of hippocampal slices showing the position of the stimulation and recording electrodes. (a2, b2) Paired-pulse facilitation at 50-, 100-, 200-, and 500-ms interpulse intervals. EPSP, excitatory postsynaptic potential. There was no difference between slices from controls and runners (P > 0.91). (a3, b3) Time course of LTP in slices from controls (▵) and runners (●) . In addition, representative examples are shown of evoked responses immediately before (Pre) and 30 min after (Post) induction of LTP. Example waveforms are the average of 20 responses recorded over a 5-min period. Population spikes were apparent in some animals in each group after LTP induction. (Scale bars under a1 and b1 indicate 250 μm.)