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. 2008 Mar 29;36(9):2852–2863. doi: 10.1093/nar/gkn098

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Over-expression of dJMJD2(1)/CG15835 induces spreading of HP1 into euchromatin. (A) S2 cells transfected with CG15835-Flag were stained with αFlag (shown in green) and αHP1 antibodies (shown in red). DNA was stained with DAPI (shown in blue). In untransfected cells, HP1 localizes mostly to a single intense spot in the nuclei (small arrow heads), which corresponds to the heterochromatic chromocentre. Cells over-expressing CG15835 (big arrow heads) show a diffuse nuclear distribution of HP1 with no specific enrichment at the chromocentre. (B) Polytene chromosomes from UAS_GAL4-CG15835-Flag; act5C-GAL4 larvae, where CG15835 is ubiquitously expressed (see text for details) (panels dJMJD2(1)/CG15835), and control wild-type larvae (panels +/+), were stained with specific αHP1 antibodies. DNA was stained with DAPI. Arrows indicate the position of the heterochromatic chromocentre.