Figure 1.

Telmisartan (blue) superimposed on the co-crystal structure of GW0072 (red) bound within the PPARγ-LBD. Telmisartan and GW0072 are Van der Waals space-filling representations, and the protein backbone by the yellow ribbon. Formation of hydrogen bonds and interactions between both ligands and the amide proton of Ser342 contribute toward stabilization of the partial agonists within the PPARγ-LBD. (Kindly provided by Dr. P.V. Desai & Professor M.A. Avery, Department of Medicinal Chemistry, University of Mississippi, USA.)