Table 2.

Skin temperature change by Shigyaku-san treatment

	Shigyaku-san (−)		Shigyaku-san (+)
	Pre-stress	Post-stress	Pre-stress	Post-stress
(Patients)
Palm	32.8 ± 2.4‡‡	31.2 ± 2.6†,‡‡‡	31.9 ± 2.0†	31.6 ± 2.3
Plantaris	26.0 ± 3.4‡‡‡	25.9 ± 3.6‡‡‡	25.9 ± 3.6	26.8 ± 3.5
(Healthy controls)
Palm	33.2 ± 3.8	36.0 ± 5.1*
Plantaris	30.0 ± 3.6	32.6 ± 3.4**

^†P < 0.05 vs. Shigyaku san (−) Pre-stress.

^‡‡P < 0.01, ^‡‡‡P < 0.001 vs. healthy controls.

*P < 0.05, **P < 0.01 vs. healthy controls, Pre-stress.

Number of healthy controls: 35 (male 10, female 25: 32 ± 14 years old).

Number of patients: 40 (male 13, female 27: 34 ± 19 years old).

Numerals: (Mean ± SD)°C. Statistics are one-way factorial ANOVA.