Table 2.
Main regional foci of generic brain activation by the working memory task
| Brain region | Approximate BA | Hemisphere | Number of voxels | Talairach coordinates
|
||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| Posterior parietal cortex | 40/39/7/19 | Left | 96 (188) | −38 (−38) | −47 (−53) | 42 (37) |
| Right | 64 (53) | 35 (32) | −61 (−64) | 37 (37) | ||
| Dorsolateral PFC | 9/10/46 | Left | 20 (54) | 46 (−43) | 5 (3) | 37 (37) |
| Right | 26 (44) | 49 (35) | 8 (44) | 31 (15) | ||
| Inferior frontal gyrus | 44/45 | Left | 11 (15) | −55 (−35) | 20 (19) | 9 (9) |
| Right | 9 | 52 | 18 | 4 | ||
| SMA/anterior cingulate | 6/32 | Medial | 32 (61) | 0 (−3) | −6 (8) | 48 (48) |
| Lateral premotor cortex | 6 | Left | 5 (34) | −35 (−43) | −3 (3) | 42 (42) |
| Precentral gyrus | 4 | Left | 10 (29) | −26 (−40) | −11 (−14) | 48 (48) |
| Right | (67) | (32) | (−6) | (53) | ||
| Extrastriate cortex | 19 | Left | 5 (49) | −32 (−40) | −69 (−69) | −13 (−13) |
| Right | (17) | (17) | (−75) | (−13) | ||
| Cerebellum | — | Left | 5 (13) | −6 (−32) | −72 (−67) | −13 (−18) |
Data are from 20 patients with schizophrenia, each scanned twice, and 10 healthy volunteers, each scanned once. The total number of voxels and Talairach coordinates for peak response in each regional cluster are shown in parentheses for the normal healthy volunteers.