Table 2.
Longitudinal MR Assessment of Leukoencephalopathy in Two Patients Treated for ALL
| Age (years) | Protocol week | Tissue volumea |
Relaxation time |
|||||
|---|---|---|---|---|---|---|---|---|
| NAWM (cc) | LEUKO (cc) | Affected white matter (%)b | NAWM (ms) | LEUKO (ms) | T1 increase (%)c | |||
| Exam 1 | ||||||||
| Subject 1 | 5.5 | 7 | 214 | — | 0 | 736 | — | 0 |
| Subject 2 | 10.4 | 5 | 298 | — | 0 | 764 | — | 0 |
| Exam 2 | ||||||||
| Subject 1 | 5.7 | 18 | 215 | 42 | 17 | 767 | 842 | 10 |
| Subject 2 | 10.6 | 19 | 247 | 54 | 18 | 773 | 838 | 8 |
| Exam 3 | ||||||||
| Subject 1 | 6.2 | 44 | 145 | 77 | 35 | 751 | 904 | 20 |
| Subject 2 | 11.1 | 43 | 192 | 117 | 38 | 789 | 885 | 12 |
| Exam 4 | ||||||||
| Subject 1 | 7.9 | 132 | 187 | 32 | 15 | 758 | 935 | 23 |
| Subject 2 | 12.8 | 132 | 220 | 31 | 12 | 789 | 810 | 3 |
Abbreviations: NAWM, normal-appearing white matter; LEUKO, leukoencephalopathy.
a
The full volume of interest encompassed two-thirds of the cerebrum.
b
The proportion of affected white matter was calculated as LEUKO/(LEUKO+NAWM).
c
The proportion of increase in T1 relaxation time was calculated as (LEUKO-NAWM)/NAWM.