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. Author manuscript; available in PMC: 2009 Apr 22.
Published in final edited form as: Neuroscience. 2008 Feb 19;153(1):338–348. doi: 10.1016/j.neuroscience.2008.02.008

Figure 3.

Figure 3

Comparison between mouse strains of the effects of four doses of murine recombinant interleukin-1 (IL-1) on core body temperature (Tcore), wakefulness (WAKE), non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep. Values are the mean ± SEM 12 h averages for the period immediately following intracerebroventricular (ICV) administration of IL-1, ie., during the dark period of the light;dark cycle. These values are expressed as differences from values obtained after ICV injection of vehicle (pyrogen-free saline), which is represented by the zero line. Statistically significant differences between mouse strains within the same dose of IL-1 are depicted by asterisks (*). Statistically significant differences among doses within the same mouse strain are depicted by the letters a, b, c, or d. These letters refer to IL-1 doses as follows: a = 2.5 ng, b = 5 ng, c = 10 ng, d = 50 ng. open bars: C57BL/6J mice; filled bars: IL-6 KO mice. An alpha value of p ≤ 0.05 was accepted as indicating statistical significance.