Table 2.
Mitotic kinesin disruptions in simple eukaryotes vs metazoans.
| Kinesin Family | S. cerevisiae | Dictyostelium | C. elegans | Drosophila | Human |
| Mitotic Function | |||||
| Kinesin-4 (Chromokin) | Kif8 | Klp-19 | Klp3A | Kif4A, Kif4B | |
| Kinesin-5 (BimC/Eg5) | Cin8, Kip1 | Kif13 | BMK1 | Klp61F | Eg5 |
| Kinesin-6 (MKLP) | Kif12 | Zen-4 | Pavarotti | MKLP1, MKLP2 | |
| Kinesin-7 (CENP-E) | Kip2 | Kif4, Kif11 | CENP-E Meta | CENP-E | |
| Kinesin- 8 (Kip3) | Kip3 | Kif10 | Klp67A | Kif18 | |
| Kinesin-13 (MCAK) | ? | Klp-7 | KLP10A | Kif2A, 2B, MCAK | |
| Kinesin-14 (NCD/Kar3) | Kar3 | Kif2 | Klp-3,15,16,17 | Ncd | KifC1 |
| Other Function | |||||
| Kinesin-3 (Unc104) | Kif1 | Kif14 | |||
| Kinesin-10 (Nod) | Nod | Kid | |||
| Kinesin12 (Xklp2) | Klp-18 |
Normal text (viable), italicized text (not viable) differentiates the individual kinesin-isoform disruptions (knockout, knockdown, or mutation) and their effects on mitosis. The bold text for the kinesin-6 family members indicates cytokinesis defects. In this case, cells can proceed through one or more divisions, but longer term, the mutated protein is essential for organism viability. References for S.c [5], D.d[7-10, 12-14], C.e [39, 47-51], D.m [40], and H.s [15, 52].