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. 2008 May 6;8:8. doi: 10.1186/1472-6793-8-8

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Copyright © 2008 Kontogeorgis et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Alterations in Cx43 Distribution and Ubiquitination with Pacing. A) Fractionation of heart samples suggests that Cx43 is reduced in the sarcolemma-enriched fraction of the paced hearts and increased in the non-sarcolemmal supernatant. B) Immunoprecipitation for Cx43 and blotting for ubiquitin suggests that there is an increased accumulation of ubiquitinated Cx43 in the paced hearts compared to sham-paced controls. In this image, mono-ubiquitinated Cx43 is seen just above the 40 kD size marker and poly-ubiquitinated forms of Cx43 appear as a slower migrating smear.