Benzylisoquinoline alkaloid biosynthetic pathway reconstructed in microbes. MAO, MAO from Micrococcus luteus (GenBank accession no. AB010716); NCS, NCS from Coptis japonica (GenBank accession no. AB267399); 6OMT, 6OMT from Coptis japonica (GenBank accession no. D29811); CNMT, CNMT from Coptis japonica (GenBank accession no. AB061863); 4′OMT, 4′OMT from Coptis japonica (GenBank accession no. D29812); CYP80G2, CYP80G2 from Coptis japonica (GenBank accession no. AB288053); BBE, BBE from Coptis japonica.