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Changes in urine flow rate (A) and urine osmolality (B) in Brattleboro rats of controls (CTR) and with SR treatment (SR) (protocol 1). V2 receptor antagonist SR was given twice a day for 3 d by subcutaneous injection. After SR administration urine flow rate was increased dramatically at day 1 and was still higher at days 2 and 3 but did not reach statistical significance. SR treatment decreased urine osmolality significantly compared with CTR rats. *P < 0.05, SR rats versus CTR rats.
