Table 2.
Characteristics at the Last Day of Experiment in Brattleboro Rats Without Treatment (CTR) or Treated With OT, Followed by Administration of SR (OT+SR) or GW (OT+GW) (Protocol 2)
| CTR | OT | OT + SR | OT + GW | |
|---|---|---|---|---|
| Body weight (g) | 214 ± 5 | 204 ± 7 | 201 ± 6 | 209 ± 5 |
| SOsm (mOsm/kg·H2O) | 310 ± 1 | 299 ± 3 | 308 ± 3 | 305 ± 2 |
| SNa (mmol/L) | 147 ± 1 | 134 ± 7 | 147 ± 2 | 143 ± 1 |
| SCrea. (mg/dl) | 0.27 ± 0.06 | 0.37 ± 0.03 | 0.27 ± 0.03 | 0.39 ± 0.08 |
| ClCrea.(ml/min/kg bw) | 8.7 ± 2.8 | 6.5 ± 1.0 | 10.3 ± 1.2 | 9.5 ± 3.7 |
| UVol (μl/min/kg bw) | 401 ± 49 | 40 ± 14* | 783 ± 170*# | 36 ± 5* |
| UOsm (mOsm/kg·H2O) | 157 ± 14 | 1074 ± 309* | 55 ± 6*# | 1204 ± 207* |
| FENa (%) | 0.76 ± 0.28 | 0.53 ± 0.14 | 0.90 ± 0.24 | 0.36 ± 0.06 |
| TCH2O (μl/min/kg) | −203 ± 34 | 85 ± 27* | −646 ± 171*# | 93 ± 17* |
*
P < 0.05 compared with CTR Brattleboro rats.
#
P < 0.05 compared with OT-treated Brattleboro rats.