Figure 2.

Glomerular lesions in anti-GBM GN in WT and FcRKO mice. Using periodic acid-Schiff staining, severe glomerular capillary space obliteration by endothelial swelling and thrombosis with fibrin deposition was seen in WT mice as early as day 5 (top). FcRKO mouse glomerular lesion was characterized by mesangial proliferation, increased matrix deposition, and mononuclear cell infiltration with lesser degree of glomerular sclerosis. Most capillary spaces were patent even at the day 14 (bottom).