Table 2.
Changes in serum biochemical parameters
| Parameter | Sevelamer (n = 33)
|
Calcium (n = 35)
|
Pa | ||
|---|---|---|---|---|---|
| Baseline | 1 Yr | Baseline | 1 Yr | ||
| Phosphorus (mg/dl; mean ± SD) | 5.8 ± 1.5 | 5.4 ± 0.1.4 | 5.7 ± 1.8 | 5.3 ± 1.9 | 0.78 |
| Calcium (mg/dl; mean ± SD) | 9.6 ± 0.7 | 9.1 ± 1.1 | 9.8 ± 1.0 | 9.3 ± 0.7b | 0.22 |
| iPTH (pg/ml; median [range]) | 167 (3 to 1958) | 275 (34 to 3890) | 113 (4 to 1369) | 227 (28 to 3636)b | 0.55 |
| 25-OH D (ng/ml; median [range]) | 16.3 (5.0 to 34.6) | 20.0 (5.4 to 53.2)b | 16.6 (5.0 to 35.3) | 17.4 (5.0 to 49.1) | 0.53 |
| 1,25-OH2 D (pg/ml; median [range]) | 6.4 (5.0 to 22.4) | 8.1 (4.5 to 83.5) | 11.8 (5.0 to 42.9) | 13.7 (4.5 to 61.5) | 0.27 |
| Total cholesterol (g/L; mean ± SD) | 1.65 ± 0.38 | 1.40 ± 0.34b | 1.72 ± 0.41 | 1.66 ± 0.41 | 0.03 |
| LDL cholesterol (g/L; mean ± SD) | 1.03 ± 0.34 | 0.68 ± 0.30b | 1.07 ± 0.37 | 1.00 ± 0.31 | <0.01 |
| HDL cholesterol (g/L; mean ± SD) | 0.50 ± 0.12 | 0.55 ± 0.14b | 0.43 ± 0.12 | 0.49 ± 0.15b | 0.87 |
| Bicarbonate (mmol/L; mean ± SD) | 19.3 ± 3.9 | 20.4 ± 3.3 | 19.7 ± 3.8 | 21.2 ± 4.1 | 0.34 |
| BSAP (μg/L; median [range]) | 11.5 (3.9 to 65.2) | 19.1 (3.9 to 174.0)b | 10.6 (3.4 to 80.1) | 12.7 (4.5 to 185.0) | 0.19 |
| Osteocalcin (ng/ml; median [range]) | 68.5 (2.9 to 896) | 84.2 (15.2 to 595) | 45.8 (2.4 to 308) | 123 (7.6 to 1122)b | 0.54 |
| N-telopeptides (nM; median [range]) | 135 (7 to 1200) | 298 (11 to 1200)b | 72 (8 to 1200) | 132 (10 to 1200)b | 0.87 |
a
Between-group difference in change from baseline assessed using Wilcoxon rank sum test.
b
P< 0.05 for within-group change from baseline assessed using Wilcoxon signed rank test. Initial lipid levels measured at screening, not baseline.