Table 3.
Changes in bone mineralization, bone turnover, and trabecular architecturea
| Parameter | Sevelamer (n = 33)
|
Calcium (n = 35)
|
Pb | ||
|---|---|---|---|---|---|
| Baseline | 1 Yr | Baseline | 1 Yr | ||
| Bone mineralization | |||||
| mineralization lag time in lamellar bone (d) | 28.2 (9.4 to 175.9) | 36.1 (0 to 153.7) | 26.1 (0.4 to 155.0) | 40.8 (2.4 to 493.8) | 0.54 |
| osteoid thickness (μm) | 9.3 (3.8 to 37.7) | 10.5 (4.8 to 16.5)c | 9.6 (4.1 to 24.0) | 10.7 (5.7 to 27.8)d | 0.71 |
| Bone turnover | |||||
| Acf (/yr) | 0.36 (0.04 to 1.84) | 0.43 (0.02 to 2.41) | 0.39 (0 to 1.54) | 0.45 (0 to 1.97) | 0.76 |
| bone formation rate/bone surface (mm3/cm2 per yr) | 1.6 (0.1 to 8.8) | 2.3 (0.2 to 13.9)e | 2.1 (0 to 8.5) | 2.5 (0.4 to 14.0) | 0.82 |
| no. of osteoblasts/bone perimeter (/100 mm) | 136.0 (0 to 882.5) | 148.2 (2.8 to 1690.6) | 87.2 (3.1 to 1109.7) | 180.8 (6.4 to 1268.1) | 0.99 |
| no. of osteoclasts/bone perimeter (/100 mm) | 31.6 (0.1 to 499.7) | 39.6 (1.2 to 172.9) | 21.4 (3.1 to 183.0) | 34.4 (0 to 223.6) | 0.72 |
| Trabecular architecture | |||||
| cancellous bone volume/tissue volume (%) | 18.4 (0.2 to 66.9) | 19.8 (10.9 to 38.9) | 21.7 (11.2 to 35.0) | 24.0 (11.5 to 59.1) | 0.10 |
| trabecular thickness (μm) | 105.7 (1.7 to 144.6) | 106.7 (70.5 to 191.9) | 119.1 (62.6 to 171.7) | 114.7 (0.6 to 188.2) | 0.96 |
| trabecular separation (μm) | 486.2 (11.8 to 773.5) | 466.5 (229.6 to 841.6) | 418.4 (247.7 to 963.9) | 385.0 (3.3 to 671.4) | 0.46 |
a
Data are median (range).
b
Between-group difference in change from baseline.
c
P = 0.030 versus baseline.
d
P = 0.026 versusbaseline.
e
P = 0.019 versusbaseline.