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Autoreactive (to α3(IV)NC1) T cells in healthy individuals are predominantly specific for peptides rapidly cleaved by Cathepsin D. The top chart shows the proportion of healthy individuals' T cells that proliferated with SI>3 to the indicated α3(IV)NC1 peptides (sequences in Table 1). The lower charts show relative cutting by Cathepsin D at 30 and 120 min.
