Table 3.
Truth table for association between rapid proteolysis and capacity to stimulate patients' T cells
| Highly scissile to Cathepsin D | Proliferation by T Cells from ≥4 of 6 Patients with Goodpasture Disease
|
Total | |
|---|---|---|---|
| P-N | P-Y | ||
| C-N | 16 | 1 | 17 |
| C-Y | 2 | 4 | 6 |
| Total | 18 | 5 | 23 |
| P = 0.00758 | |||
Each peptide in the set of 23 used to interrogate patients' T cells was classified as in Table 2. The proportion of T cell stimulatory peptides that also contained highly Cathepsin D–scissile peptide bonds was higher than expected from the overall frequency of highly scissile peptide bonds in the peptide set. Fisher exact test: P = 0.00758.