TABLE 3.
Comparison of Tissue Volumes between Acute Lymphoblastic Leukemia Survivors who Received Either Chemotherapy Alone or Chemotherapy plus Cranial Irradiation and between a Control Group of Healthy Siblings and Age-Matched and Gender-Matched Acute Lymphoblastic Leukemia Survivors who Received Chemotherapy Alone
| Mean ± SD tissue volume |
||||
|---|---|---|---|---|
| Group | White matter (mL) | Gray matter (mL) | CSF (mL) | Age at examination (yrs) |
| ALL survivors | ||||
| Chemotherapy alone | 142.5 ± 26.4 | 315.9 ± 27.4 | 29.7 ± 8.3 | 9.8 ± 3.1 |
| Chemotherapy and irradiation | 128.8 ± 24.2 | 313.5 ± 29.8 | 37.4 ± 19.8 | 11.1 ± 2.6 |
| P value | 0.02a | 0.69 | 0.05a | 0.04a |
| Control group | ||||
| Chemotherapy alone | 142.6 ± 23.7 | 311.2 ± 28.4 | 31.2 ± 8.2 | 11.7 ± 2.4 |
| Healthy sibling | 155.2 ± 21.0 | 310.3 ± 18.5 | 26.5 ± 4.3 | 12.0 ± 2.7 |
| P value | 0.03a | 0.87 | < 0.01a | 0.68 |
SD: standard deviation; CSF: cerebrospinal fluid; ALL: acute lymphoblastic leukemia.
a
In a statistical comparison between the groups, the difference was significant for this variable.