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Schematic of the 3D kernel used in the third leukoencephalopathy algorithm. The pixel shown in gray is the reference pixel for which the gradient magnitude value is determined, while the pixels represented as black identify the neighbors used in the calculation of the gradient magnitude value. The center group of pixels represents the in-plane component of the kernel, while the left and right represent pixels in the MR slices superior and inferior to the reference pixel, respectively.
