Table 1.

Average Kappa scores with standard deviations between the semi-automated segmentation algorithms and the manual segmentations

	Observer 1	Observer 2
Original leukoencephalopathy segmentation	0.651 ± 0.154	0.602 ± 0.186
Second leukoencephalopathy segmentation with 2-D gradient threshold and a priori maps	0.653 ± 0.137a	0.615 ± 0.136a
Third leukoencephalopathy segmentation with 3-D gradient threshold and a priori maps	0.744±0.114b	0.699±0.095c

Paired t-tests were computed between the original algorithm and the two modified techniques.

^aNot significant;

^bp = 0.015;

^cp = 0.024.