Table 2.
Mean extinction (±SEM; in arbitrary units) of mRNA expression of the MR and GR in three hippocampal subfields
| Treatment | MR
|
GR
|
||||
|---|---|---|---|---|---|---|
| CA1 | CA3 | DG | CA1 | CA3 | DG | |
| Acute | ||||||
| Vehicle | 11.0 ± 0.2 | 9.2 ± 0.3 | 11.2 ± 0.3 | 19.1 ± 0.4 | 12.0 ± 0.3 | 18.9 ± 0.6 |
| Corticosterone | 10.7 ± 0.4 | 9.2 ± 0.3 | 11.1 ± 0.4 | 18.5 ± 0.4 | 12.4 ± 0.4 | 17.6 ± 0.4 |
| 1 Week | ||||||
| Vehicle | 12.2 ± 0.3 | 9.5 ± 0.4 | 11.4 ± 0.4 | 19.0 ± 0.4 | 11.3 ± 0.4 | 18.2 ± 0.4 |
| Corticosterone | 9.7 ± 0.9* | 8.6 ± 0.7 | 9.6 ± 0.7* | 15.2 ± 1.0* | 11.5 ± 1.0 | 15.4 ± 0.8* |
| 3 Weeks | ||||||
| Vehicle | 11.8 ± 0.3 | 9.2 ± 0.4 | 10.9 ± 0.2 | 19.2 ± 0.2 | 12.1 ± 0.5 | 18.9 ± 0.4 |
| Corticosterone | 9.6 ± 0.3* | 8.4 ± 0.4 | 9.0 ± 0.2* | 17.0 ± 0.3* | 11.8 ± 0.3 | 16.6 ± 0.4* |
The MR and GR mRNA expression is reduced after 1 and 3 weeks corticosterone treatment in both the dentate gyrus and the CA1 area, but not in the CA3 region. The number of animals used per group is given in Table 1. In two groups, however, extra animals were incorporated, one animal in the acute vehicle group (n = 9) and three animals in the acute corticosterone group (n = 9). *, P < 0.05.